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KMID : 0368820210600030186
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Journal of the Korean Neuropsychiatr Association
2021 Volume.60 No. 3 p.186 ~ p.192
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Korean Medication Algorithm Project for Depressive Disorder 2021 (II): The Subtypes of Depression
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Park Young-Min
Seo Jeong-Seok
Woo Young-Sup
Bahk Won-Myong
Kim Won
Jeong Jong-Hyun
Shim Se-Hoon
Lee Jung-Goo
Jang Seung-Ho
Wang Sheng-Min
Jung Myung-Hun
Sung Hyung-Mo
Choo Il-Han
Yoon Bo-Hyun
Lee Sang-Yeol
Jon Duk-In
Min Kyung-Joon
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Abstract
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Objectives The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) was developed in 2002 and revised in 2006, 2012, 2017. In 2021, the fifth edition was published.
This edition reflected new findings and the latest trends in the areas of pharmacological treatment.
The aim of this study is to present strategies and treatment options according to the subtype of depression using data from the KMAP-DD-2021.
Methods Ninety-seven psychiatrists with clinical experience in depressive disorder were selected.
The questionnaires for KMAP-DD 2021 were sent to participants via mail. KMAP-DD 2021 consists of overall treatment strategies and treatment options under specific circumstances.
Each treatment strategy or treatment option was evaluated with an overall score of nine and was divided into the three phases of recommendation that include primary, secondary, and tertiary.
Results For persisting depressive disorder, antidepressant monotherapy including selectiveserotonin reuptake inhibitor (SSRI) (escitalopram, fluoxetine, sertraline, paroxetine), serotoninnorepinephrine reuptake inhibitor (SNRI) (desvenlafaxine, venlafaxine, duloxetine, milnacipran), vortioxetine, and mirtazapine, was recommended as first-line medications. For melancholia of major depressive disorder, SSRI, SNRI, vortioxetine, and mirtazapine also were recommended as first-line medications. For mixed features, SSRI, bupropion, mirtazapine, SNRI, except for duloxetine, and milnacipran were recommended as first-line medications. For anxious distress, SSRI, mirtazapine, and SNRI, except milnacipran, were recommended as first-line medications.
Conclusion The preferences of antidepressants by experts differed according to the subtype of depression. These findings suggest that experts treat patients with a major depressive disorder after considering the subtype of depression involved.
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KEYWORD
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Korean Medication Algorithm Project, Major depressive disorder, Persisting depressive disorder, Subtype
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